Glutathione S-Transferases in the Biosynthesis of Sulfur-Containing Secondary Metabolites in Brassicaceae Plants.
Identifieur interne : 000223 ( Main/Exploration ); précédent : 000222; suivant : 000224Glutathione S-Transferases in the Biosynthesis of Sulfur-Containing Secondary Metabolites in Brassicaceae Plants.
Auteurs : Paweł Czerniawski [Pologne] ; Paweł Bednarek [Pologne]Source :
- Frontiers in plant science [ 1664-462X ] ; 2018.
Abstract
Plants in the Brassicaceae family have evolved the capacity to produce numerous unique and structurally diverse sulfur-containing secondary metabolites, including constitutively present thio-glucosides, also known as glucosinolates, and indole-type phytoalexins, which are induced upon pathogen recognition. Studies on the glucosinolate and phytoalexin biosynthetic pathways in the model plant Arabidopsis thaliana have shown that glutathione donates the sulfur atoms that are present in these compounds, and this further suggests that specialized glutathione S-transferases (GSTs) are involved in the biosynthesis of glucosinolates and sulfur-containing phytoalexins. In addition, experimental evidence has shown that GSTs also participate in glucosinolate catabolism. Several candidate GSTs have been suggested based on co-expression analysis, however, the function of only a few of these enzymes have been validated by enzymatic assays or with phenotypes of respective mutant plants. Thus, it remains to be determined whether biosynthesis of sulfur-containing metabolites in Brassicaceae plants requires specific or nonspecific GSTs.
DOI: 10.3389/fpls.2018.01639
PubMed: 30483292
PubMed Central: PMC6243137
Affiliations:
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Studies on the glucosinolate and phytoalexin biosynthetic pathways in the model plant <i>Arabidopsis thaliana</i> have shown that glutathione donates the sulfur atoms that are present in these compounds, and this further suggests that specialized glutathione <i>S</i>-transferases (GSTs) are involved in the biosynthesis of glucosinolates and sulfur-containing phytoalexins. In addition, experimental evidence has shown that GSTs also participate in glucosinolate catabolism. Several candidate GSTs have been suggested based on co-expression analysis, however, the function of only a few of these enzymes have been validated by enzymatic assays or with phenotypes of respective mutant plants. Thus, it remains to be determined whether biosynthesis of sulfur-containing metabolites in Brassicaceae plants requires specific or nonspecific GSTs.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">30483292</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>30</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">1664-462X</ISSN><JournalIssue CitedMedium="Print"><Volume>9</Volume><PubDate><Year>2018</Year></PubDate></JournalIssue><Title>Frontiers in plant science</Title><ISOAbbreviation>Front Plant Sci</ISOAbbreviation></Journal><ArticleTitle>Glutathione <i>S</i>-Transferases in the Biosynthesis of Sulfur-Containing Secondary Metabolites in Brassicaceae Plants.</ArticleTitle><Pagination><MedlinePgn>1639</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fpls.2018.01639</ELocationID><Abstract><AbstractText>Plants in the Brassicaceae family have evolved the capacity to produce numerous unique and structurally diverse sulfur-containing secondary metabolites, including constitutively present thio-glucosides, also known as glucosinolates, and indole-type phytoalexins, which are induced upon pathogen recognition. Studies on the glucosinolate and phytoalexin biosynthetic pathways in the model plant <i>Arabidopsis thaliana</i> have shown that glutathione donates the sulfur atoms that are present in these compounds, and this further suggests that specialized glutathione <i>S</i>-transferases (GSTs) are involved in the biosynthesis of glucosinolates and sulfur-containing phytoalexins. In addition, experimental evidence has shown that GSTs also participate in glucosinolate catabolism. Several candidate GSTs have been suggested based on co-expression analysis, however, the function of only a few of these enzymes have been validated by enzymatic assays or with phenotypes of respective mutant plants. Thus, it remains to be determined whether biosynthesis of sulfur-containing metabolites in Brassicaceae plants requires specific or nonspecific GSTs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Czerniawski</LastName><ForeName>Paweł</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bednarek</LastName><ForeName>Paweł</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznań, Poland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>11</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Plant Sci</MedlineTA><NlmUniqueID>101568200</NlmUniqueID><ISSNLinking>1664-462X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brassicaceae</Keyword><Keyword MajorTopicYN="N">glucosinolate</Keyword><Keyword MajorTopicYN="N">glutathione</Keyword><Keyword MajorTopicYN="N">glutathione S-transferase (GST)</Keyword><Keyword MajorTopicYN="N">sulfur-containing phytoalexin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>07</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>10</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>11</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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